When it comes to managing weight and blood glucose levels,  top three weight loss drugs—Semaglutide, Monjouro, and Dulaglutide—have garnered attention. Let us explore their differences:

1. Semaglutide: (such as Ozempic, Rybelsus tablets, & Wegovy)
   • Weight Loss Effects: Semaglutide has been associated with weight loss. It works by mimicking the action of a hormone called GLP-1, which helps regulate blood sugar levels and appetite. Clinical trials have shown that patients using Ozempic achieved an impressive 26.6% weight loss over 84 weeks¹.
   • Mechanism: Semaglutide is an FDA-approved medication for obesity treatment. Its active ingredient, Semaglutide, belongs to the class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists. Semaglutide improves satiety, breaks down fat, and reduces sugar cravings, contributing to weight loss.
   • GLP-1 Receptor Activation: GLP-1 is a hormone produced in the gut in response to food intake. Semaglutide activates GLP-1 receptors in the pancreas and the brain.
   • Effects:
     1. Semaglutide stimulates insulin release from the pancreas. Insulin helps lower blood sugar levels by promoting glucose uptake into cells.
     2. Semaglutide inhibits the release of glucagon (another pancreatic hormone). Glucagon raises blood sugar levels by promoting glucose release from the liver.
     3. Semaglutide slows down stomach emptying after meals, leading to controlled blood sugar levels.
   • Appetite Regulation: By acting on the brain’s appetite center, Semaglutide suppresses appetite and increases feelings of fullness¹.
     • Side Effects: Common side effects include nausea, vomiting, abdominal pain, and constipation².
     • Comparison: Semaglutide is the active ingredient found in each of these brands. Weight loss results are similar.
     • What do we offer at our clinic? We use an accredited compounding pharmacy, which formulates our Semaglutide using active pharmaceutical ingredients (APIs) from FDA-registered facilities.
     • What have our patients experienced? Our clients are experiencing successful weight loss and all have felt loss of hunger and food cravings, and fill fuller while eating less food. A small number of clients have experienced mild side effects including nausea and constipation, which are usually temporary.

2. Tirzepatide: (such as Mounjaro & Zepbound)
   • Weight Loss Efficacy: Recent clinical trials suggest that Tirzepatide brands are even more effective than Semaglutide brands. Patients taking Mounjaro experienced an average 13% body weight loss after 52 weeks of treatment³.
   • Mechanism: Tirzepatide is also a GLP-1 receptor agonist. It mimics satiety hormones in the body and affects appetite regulation in the brain. Tirzepatide enhances satiety, promotes fat breakdown, and reduces sugar cravings.
   • Effects:
     1. Like Semaglutide, Tirzepatide stimulates insulin release, reducing hunger.
     2. Tirzepatide additionally stimulates another gut hormone called GIP. This dual action may contribute to its effectiveness in weight loss^{2 3}.
     3. GIP helps protect the small intestine from acid damage by reducing stomach acid production and influences the rate at which food moves through the stomach. By slowing down stomach emptying, it ensures efficient digestion and nutrient absorption⁴.
   • Side Effects: Similar to Semaglutide, Tirzepatide may cause nausea, vomiting, abdominal pain, and constipation¹.
   • What do we offer at our clinic? We use an accredited compounding pharmacy, which formulates our Tirzepatide using active pharmaceutical ingredients (APIs) from FDA-registered facilities.
   • What have our patients experienced? Our clients are experiencing success with weight loss drugs and all have felt loss of hunger and food cravings, and fill fuller while eating less food. Currently our clients have not reported adverse side effects.

3. Dulaglutide: (such as Trulicity)
   • Weight Effects: Dulaglutide can impact weight loss, although it is primarily FDA-approved for regulating insulin and blood sugar in Type 2 diabetes patients.
   • Mechanism: Dulaglutide is a GLP-1 receptor agonist. It simulates feelings of fullness, making it easier for individuals with diabetes to eat less and lose weight¹.
   • Side Effects: Dulaglutide shares side effects with Semaglutide, including constipation, abdominal pain, and appetite changes².
   • What do we offer at our clinic? We do not offer Dulaglutide as an option to our clients.

Contact Results Weight Loss and Med Spa to learn more about our weight loss programs. 512-295-0173

Sources: (1) healthline.com, (2) everlywell.com, (3) glphub.com, (4) Britannica.com/science